Endothelial Progenitor Cells Are Related toGlycemicControl inChildrenWithType 1 DiabetesMellitus Over Time
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چکیده
RESULTSdEPCs were significantly reduced in T1DM children versus CO (609 6 359 vs. 1,165 6 484, P , 0.001). Multivariate regression modeling revealed that glycated hemoglobin A1c (HbA1c) was the strongest independent predictor of EPCs (b =20.355, P, 0.001). Overall glycemic control at the beginning and end of study did not differ (7.86 1.2 vs. 7.86 1.2 relative %, P = NS), but we observed individual HbA1c changes of24.30/+3.10 relative %. The strongest EPC increase was observed in the patients with the most favorable HbA1c lowering during the 1-year follow-up. Accordingly, the strongest EPC decrease was demonstrated in the patients with the strongest HbA1c worsening during the time period.
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تاریخ انتشار 2013